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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
12.42
Human Site:
T798
Identified Species:
18.22
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
T798
S
S
K
A
L
A
Q
T
L
P
P
P
T
A
A
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
T798
P
S
K
A
L
A
Q
T
L
P
P
P
T
A
A
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
T798
P
S
K
A
L
A
R
T
L
P
P
P
T
A
A
Dog
Lupus familis
XP_546656
989
110956
S798
A
A
D
G
E
S
N
S
V
I
C
N
C
G
Q
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
A798
T
R
P
S
K
T
V
A
Q
A
L
L
P
P
T
Rat
Rattus norvegicus
XP_002742497
1001
111922
A796
T
G
P
S
K
A
V
A
Q
T
L
L
P
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
S841
N
R
P
P
N
P
S
S
G
T
H
L
S
F
P
Chicken
Gallus gallus
NP_001025807
1020
114626
L800
N
M
A
T
G
H
L
L
Y
L
S
S
T
R
A
Frog
Xenopus laevis
NP_001085699
1022
114003
P803
Q
T
K
T
L
K
P
P
V
V
K
P
S
T
S
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
R797
R
P
P
A
P
R
P
R
A
D
P
G
L
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
G800
W
S
S
G
P
G
G
G
G
S
G
G
G
G
G
Honey Bee
Apis mellifera
XP_394050
958
109977
Q764
K
S
R
N
T
K
Q
Q
H
K
I
W
G
D
I
Nematode Worm
Caenorhab. elegans
O61660
759
85420
G571
G
L
K
E
I
C
D
G
R
R
Q
K
Q
E
V
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
T491
T
Q
A
P
P
L
L
T
E
A
D
L
I
T
L
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
D719
L
G
C
I
G
G
C
D
E
T
L
R
Q
L
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
T738
Q
L
I
D
I
C
G
T
G
S
R
S
Q
A
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
93.3
86.6
0
N.A.
0
6.6
N.A.
0
13.3
20
13.3
N.A.
6.6
13.3
6.6
6.6
P-Site Similarity:
100
93.3
93.3
33.3
N.A.
13.3
20
N.A.
20
20
46.6
13.3
N.A.
6.6
20
13.3
13.3
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
0
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
13
25
0
25
0
13
7
13
0
0
0
25
25
% A
% Cys:
0
0
7
0
0
13
7
0
0
0
7
0
7
0
0
% C
% Asp:
0
0
7
7
0
0
7
7
0
7
7
0
0
7
0
% D
% Glu:
0
0
0
7
7
0
0
0
13
0
0
0
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
7
13
0
13
13
13
13
13
19
0
7
13
13
13
7
% G
% His:
0
0
0
0
0
7
0
0
7
0
7
0
0
0
0
% H
% Ile:
0
0
7
7
13
0
0
0
0
7
7
0
7
0
13
% I
% Lys:
7
0
32
0
13
13
0
0
0
7
7
7
0
0
0
% K
% Leu:
7
13
0
0
25
7
13
7
19
7
19
25
7
7
7
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
13
0
0
7
7
0
7
0
0
0
0
7
0
0
0
% N
% Pro:
13
7
25
13
19
7
13
7
0
19
25
25
13
13
13
% P
% Gln:
13
7
0
0
0
0
19
7
13
0
7
0
19
7
7
% Q
% Arg:
7
13
7
0
0
7
7
7
7
7
7
7
0
7
7
% R
% Ser:
7
32
7
13
0
7
7
13
0
13
7
13
13
0
7
% S
% Thr:
19
7
0
13
7
7
0
32
0
19
0
0
25
13
13
% T
% Val:
0
0
0
0
0
0
13
0
13
7
0
0
0
0
7
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _